Chronic active Epstein-Barr virus infection treated with PEG-aspargase: A case report

BACKGROUND Chronic active Epstein-Barr virus infection (EBV) is a systemic EBV-positive lymphoproliferative disease, which may lead to fatal illness. There currently no standard treatment regimen for chronic EBV (CAEBV), and hematopoietic stem cell transplantation the only effective treatment. We here report CAEBV patient treated with PEG-aspargase, who achieved negative EBV-DNA. CASE SUMMARY A 33-year-old female Chinese had fever approximately 3 mo was admitted our hospital in December 2017. EBV-DNA positive high copy number. She diagnosed EB infection. PEG-aspargase administered at dose of 1500 U/m2 14-d interval, resulting eradication more than 6 mo. The effect this excellent. CONCLUSION chemotherapy containing be further considered.